2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]-
LCH-7749944
CAS: 796888-12-5
Molecular Formula: C20H22N4O2
2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]- - Names and Identifiers
2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]- - Physico-chemical Properties
| Molecular Formula | C20H22N4O2 |
| Molar Mass | 350.41 |
| Density | 1.272±0.06 g/cm3(Predicted) |
| Boling Point | 580.0±58.0 °C(Predicted) |
| Appearance | Solid |
| pKa | 7.68±0.30(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| MDL | MFCD04218695 |
2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]- - Reference Information
| biological activity | LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with IC50 of 14.93 μm. LCH-7749944 by down-regulating PAK4/c-Src/EGFR/cyclin D1 pathway effectively inhibits the proliferation of human gastric cancer cells and induces apoptosis. |
| Cell Line: | MKN-1, BGC823, SGC7901 and MGC803 human gastric cancer cells SGC7901 cells SGC7901 cells SGC7901 cells |
| Concentration: | 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 μM 5, 10, 20 μM 5, 10, 20 μM 5, 10, 20, 30 μM |
| Incubation Time: | 24 hours 12, 24, 48 hours 12, 24, 48 hours 24 hours |
| Result: | Inhibited the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner. Induced apoptosis of SGC7901 cells. Prominently induced a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase. Dramatically decreased levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner. |
Last Update：2024-04-09 19:05:17
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